Lurasidone: Due to the antagonism of lurasidone at alpha-1 adrenergic receptors, the drug may enhance the hypotensive effects of alpha-blockers and other antihypertensive agents. If concurrent use of lurasidone and antihypertensive agents is necessary, patients should be counseled on measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning and rising slowly from a seated position. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. buy cilostazol next day delivery cilostazol
Hytrin, and shortly after taking the drug during the first week of treatment. It can also occur if you stop taking the drug and then re-start treatment. Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Terazosin also alters lipid metabolism, decreasing the levels of total cholesterol, low-density lipoprotein LDL cholesterol, and very low-density lipoprotein VLDL cholesterol. Significant changes were not observed in triglycerides and high-density lipoprotein. The implications of these changes are not known. Terazosin also does not worsen and may improve LVH, does not worsen insulin resistance, and causes only mild sexual dysfunction.
Goal is to achieve and maintain optimal control of BP; individualize specific target BP based on consideration of multiple factors, including patient age and comorbidities, and currently available evidence from clinical studies. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. QD was co-administered with Tikosyn 500 mcg BID for 5 days following 2 days of diuretic use at half dose. In patients receiving HCTZ alone, dofetilide AUC increased by 27% and C max by 21%. However, the pharmacodynamic effect increased by 197% QTc increase over time and by 95% maximum QTc increase. In patients receiving HCTZ in combination with triamterene, dofetilide AUC increased by 30% and C max by 16%. However, the pharmacodynamic effect increased by 190% QTc increase over time and by 84% maximum QTc increase. The pharmacodynamic effects can be explained by a combination of the increase in dofetilide exposure and the reductions in serum potassium. In the DIAMOND trials, 1252 patients were treated with Tikosyn and diuretics concomitantly, of whom 493 died compared to 508 deaths among the 1248 patients receiving placebo and diuretics.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Rasagiline: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Careful monitoring of blood pressure is suggested during concurrent therapy with antihypertensives such as alpha-blockers. Patients should be instructed to rise slowly from a sitting position, and to report syncope or changes in blood pressure or heart rate to their health care provider.
Terazosin is available only with your doctor's prescription. Kaplan NM. Choice of initail therapy for hypertension. JAMA. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. The DIAMOND trials therefore provide evidence of a method of safe use of Tikosyn in a population susceptible to ventricular arrhythmias. Diazoxide: Additive hypotensive effects can occur with the concomitant administration of diazoxide with other antihypertensive agents. This interaction can be therapeutically advantageous, but dosages must be adjusted accordingly. The manufacturer advises that IV diazoxide should not be administered to patients within 6 hours of receiving other antihypertensive agents. Patients to be discharged on Tikosyn therapy from an inpatient setting as described above must have an adequate supply of Tikosyn, at the patient's individualized dose, to allow uninterrupted dosing until the patient can fill a Tikosyn prescription. In addition to the use of the medicine your doctor has prescribed, treatment for your high blood pressure may include weight control and care in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet. Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. Testicular weights and morphology were unaffected by treatment. Terazosin than in patients receiving placebo. The incidence of urinary tract infection was significantly lower in the patients receiving Terazosin than in patients receiving placebo. An analysis of the incidence rate of hypotensive adverse events see adjusted for the length of drug treatment has shown that the risk of the events is greatest during the initial seven days of treatment, but continues at all time intervals. Baclofen: Baclofen has been associated with hypotension. Concurrent use with baclofen and antihypertensive agents may result in additive hypotension. Dosage adjustments of the antihypertensive medication may be required. Remove the cap from the tube.
Ethinyl Estradiol: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Tikosyn dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. This effect, and the related increase in effective refractory period, is observed in the atria and ventricles in both resting and paced electrophysiology studies. The increase in QT interval observed on the surface ECG is a result of prolongation of both effective and functional refractory periods in the His-Purkinje system and the ventricles. The use of Tikosyn in conjunction with other drugs that prolong the QT interval has not been studied and is not recommended. Such drugs include phenothiazines, cisapride, bepridil, tricyclic antidepressants, certain oral macrolides, and certain fluoroquinolones. Class I or Class III antiarrhythmic agents should be withheld for at least three half-lives prior to dosing with Tikosyn. Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Phentermine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Medication. There are different kinds of medication used to treat BPH. Your doctor has prescribed terazosin hydrochloride for you. See "What Terazosin Hydrochloride Does to Treat BPH" below. Terazosin capsules, USP are indicated for the treatment of symptomatic benign prostatic hyperplasia BPH. There is a rapid response, with approximately 70% of patients experiencing an increase in urinary flow and improvement in symptoms of BPH when treated with Terazosin capsules, USP. The long-term effects of Terazosin capsules, USP on the incidence of surgery, acute urinary obstruction or other complications of BPH are yet to be determined. Guaifenesin; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. If high blood pressure is not treated, over time, the increased pressure can damage blood vessels or it can cause the heart to work too hard and may decrease the flow of blood to the heart, brain, and kidneys. As a result, these organs may become damaged and not function correctly. If high blood pressure is controlled, this damage is less likely to happen. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Terazosin is used alone or with other drugs to treat high blood pressure hypertension. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication works by relaxing blood vessels so blood can flow more easily. Carbetapentane; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Guthrie R "Terazosin in the treatment of hypertension and symptomatic benign prostatic hyperplasia - a primary care trial. James PA, Oparil S, Carter BL et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee JNC 8. JAMA. disulfiram
Table 6 shows the frequency by randomized dose of serious arrhythmias and conduction disturbances reported as adverse events in patients with supraventricular arrhythmias. FDA pregnancy category C. It is not known whether terazosin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Guaifenesin; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Tikosyn dofetilide shows Vaughan Williams Class III antiarrhythmic activity. It has also been used to help treat bladder problems in women. Isoproterenol infusion into anesthetized dogs with cardiac pacing rapidly attenuates the dofetilide-induced prolongation of atrial and ventricular effective refractory periods in a dose-dependent manner. Magnesium sulfate, administered prophylactically either intravenously or orally in a dog model, was effective in the prevention of dofetilide-induced Torsade de Pointes ventricular tachycardia. Similarly, in man, intravenous magnesium sulfate may terminate Torsade de Pointes, irrespective of cause. In volunteers with varying degrees of renal impairment and patients with arrhythmias, the clearance of dofetilide decreases with decreasing creatinine clearance. As a result, and as seen in clinical studies, the half-life of dofetilide is longer in patients with lower creatinine clearances. Program of monitoring or "Watchful Waiting". Some men have an enlarged prostate gland, but no symptoms, or symptoms that are not bothersome. If this applies, you and your doctor may decide on a program of monitoring including regular checkups, instead of medication or surgery. If you have a history of prostate cancer, you may need a dose adjustment or special tests to safely take terazosin. If therapy is interrupted for several days or longer, restart using initial dosage regimen. In all three studies, both symptom scores and peak urine flow rates showed statistically significant improvement from baseline in patients treated with Terazosin capsules from week 2 or the first clinic visit and throughout the study duration.
Additional adverse events have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. The safety profile of patients treated in the long-term study was similar to that observed in the controlled studies. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Store at room temperature away from light and moisture. not store in the bathroom. Capsules should be stored between 68-77 degrees F 20-25 degrees C because they may soften or melt if stored at higher than recommended temperatures. Keep all away from children and pets. Signs of may be milder and come on suddenly or gradually over weeks or months, and the symptoms may come and go. Symptoms alone cannot be used to determine the type of prostatitis you have. Brexpiprazole: Due to brexpiprazole's antagonism at alpha 1-adrenergic receptors, the drug may enhance the hypotensive effects of alpha-blockers and other antihypertensive agents. There is no known antidote to Tikosyn; treatment of overdose should therefore be symptomatic and supportive. The most prominent manifestation of overdosage is likely to be excessive prolongation of the QT interval. If patients do not convert to normal sinus rhythm within 24 hours of initiation of Tikosyn therapy, electrical conversion should be considered. Patients continuing on Tikosyn after successful electrical cardioversion should continue to be monitored by electrocardiography for 12 hours post cardioversion, or a minimum of 3 days after initiation of Tikosyn therapy, whichever is greater. American Urological Association Panel Members. American Urological Association guideline: Management of benign prostatic hyperplasia BPH. Linthicum, MD. 2010. From AUA website. If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose. pharmacy buy arcoxia usa
Lepor H, Meretyk S, Knapp-Maloney G. The safety, efficacy and compliance of terazosin therapy for benign prostatic hyperplasia. J Urol. Carbinoxamine; Hydrocodone; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Desloratadine; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Concomitant use of HCTZ alone or in combination with triamterene is contraindicated. Prior to initiation of Tikosyn therapy, the patient should be advised to read the Medication Guide and reread it each time therapy is renewed in case the patient's status has changed. The patient should be fully instructed on the need for compliance with the recommended dosing of Tikosyn and the potential for drug interactions, and the need for periodic monitoring of QTc and renal function to minimize the risk of serious abnormal rhythms.
The concomitant use of hydrochlorothiazide alone or in combinations such as with triamterene with Tikosyn is contraindicated see because this has been shown to significantly increase dofetilide plasma concentrations and QT interval prolongation. AUC. Increased incidences of testicular atrophy and epididymal oligospermia and a reduction in testicular weight were, however, observed in other studies in rats. Reduced testicular weight and increased incidence of testicular atrophy were also consistent findings in dogs and mice. Eat nutritious meals to promote your general health. This initial dosing regimen should be strictly observed to minimize the potential for severe hypotensive effects. Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems in urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely. Acrivastine; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Metabolic side effects have included decreases in serum triglycerides and VLDL cholesterol, and increases in HDL cholesterol. Terazosin may counterbalance deleterious effects on the lipid profile associated with thiazide diuretics, making it a reasonable drug to use in combination with these agents. Bortezomib: Patients on antihypertensive agents receiving bortezomib treatment may require close monitoring of their blood pressure and dosage adjustment of their medication. During clinical trials of bortezomib, hypotension was reported in roughly 12 percent of patients. Terazosin capsules work by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. Overdose symptoms may include extreme dizziness or fainting. Symptoms may include dizziness; weakness. Chlorpheniramine; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. In the DIAMOND population, adverse events other than those related to the post-infarction and heart failure patient population were generally similar to those seen in the supraventricular arrhythmia groups. Associated Press American Diabetes Association. Diabetics urged: drop blood pressure. Chicago, IL; 2000 Aug 29. Press Release from web site. Population pharmacokinetic analyses were conducted on plasma concentration data from 1445 patients in clinical trials to examine the effects of concomitant medications on clearance or volume of distribution of dofetilide. Concomitant medications were grouped as ACE inhibitors, oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular organic cation transport, and QTc-prolonging drugs. Nasal congestion and symptoms of sinusitis or dyspnea may be due to alpha-adrenergic blockade. price moduretic
Abnormal vision, conjunctivitis, tinnitus. If Terazosin capsules are helping you, you should notice an effect on your particular symptoms in 2 to 4 weeks of starting to take the medication. Patients received a median duration of therapy of greater than one year. Initially, 1 mg daily at bedtime. Kaplan NM. Initial treatment of adult patients with essential hypertension. Part 2: alternating monotherapy is the preferred treatment. Pharmacotherapy.
Pfizer Roerig. Cardura doxazosin mesylate tablets prescribing information. New York, NY; 1994 Dec. Rituximab: Patients should not take antihypertensive agents 12 hours prior to rituximab infusions due to the possibility of hypotension occurring during the rituximab infusion. Hypersensitivity reactions have been reported, including anaphylaxis and rashes. About Prostate Specific Antigen PSA. Your doctor may have done a blood test called PSA. Your doctor is aware that Terazosin capsules do not affect PSA levels. You may want to ask your doctor more about this if you have had a PSA test done. If the QTc is greater than 440 msec 500 msec in patients with ventricular conduction abnormalities Tikosyn is contraindicated. If heart rate is less than 60 beats per minute, QT interval should be used. Enflurane: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Further dose response and dose duration studies are being carried out. Blood pressure should be measured at the end of the dose interval; if response is not satisfactory, patients may be tried on a larger dose or twice daily dosing regimen. The latter should also be considered if possibly blood pressure-related side effects, such as dizziness, palpitations, or orthostatic complaints, are seen within a few hours after dosing. Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Wilde MI, Fitton A, Sorkin EM. Terazosin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in benign prostatic hypertrophy. Drugs Aging. Andersson KE. Current concepts in the treatment of disorders of micturition. Drugs. Terazosin than in patients receiving placebo. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials. Ethinyl Estradiol; Desogestrel: Estrogen-containing oral contraceptive may induce fluid retention and may increase blood pressure in some patients taking antihypertensive agents. Such patients should be monitored to confirm that the desired antihypertensive effect is being obtained. Isoflurane: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. paxil
May take with food. Terazosin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Patients should also be told that drowsiness or somnolence can occur with Terazosin capsules, requiring caution in people who must drive or operate heavy machinery. Haloperidol: In general, haloperidol should be used cautiously with antihypertensive agents due to the possibility of additive hypotension. Day 23 reflecting a steady state of dosing. A linear relationship between mean QTc increase and dofetilide dose was also seen in patients with renal impairment, in patients with ischemic heart disease, and in patients with supraventricular and ventricular arrhythmias. May consider combined therapy with an α 1-adrenergic blocker and 5α-reductase inhibitor for men with bothersome moderate to severe BPH and demonstrable prostatic enlargement. 59 Has been more effective than therapy with either drug alone in preventing long-term BPH symptom progression. 59 Men at risk for BPH progression are most likely to benefit from combination therapy. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Follow the instructions on how to properly prime the bottle if you are using it for the first time or if you have not used it for a week or more. Spray this medication in the nose, usually 1 to 3 times a day as directed by your doctor. If the dose is more than 1 spray, spray half the dose in each nostril. For example, if the dose is 2 sprays, give 1 spray in each nostril. What are the possible side effects of Tikosyn? Tikosyn can cause serious side effects, including a type of abnormal heartbeat called Torsade de Pointes, which can lead to death. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Analysis of the effect of Terazosin capsules on individual urinary symptoms demonstrated that compared to placebo, Terazosin capsules significantly improved the symptoms of hesitancy, intermittency, impairment in size and force of urinary stream, sensation of incomplete emptying, terminal dribbling, daytime frequency and nocturia. Trazodone: Due to additive hypotensive effects, patients receiving antihypertensive agents concurrently with trazodone may have excessive hypotension. Decreased dosage of the antihypertensive agent may be required when given with trazodone. Some MEDICINES MAY INTERACT with terazosin.
Terazosin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Acetaminophen; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Hytrin is 1 mg at bedtime, with dosage gradually increased to 10 mg. To treat hypertension, the starting dose is 1 mg at bedtime. The usual recommended dose range is 1 mg to 5 mg administered once a day; some patients benefit from doses as high as 20 mg per day. Hytrin may interact with sildenafil, tadalafil, vardenafil, or other blood pressure medications. Tell your doctor all medications you use. Hytrin should be used only when prescribed during pregnancy. It is not known if this drug passes into breast milk. Consult your doctor before breastfeeding. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Do not stop taking any medications without consulting your healthcare provider. Hernandez RH, Angeligreaves M, Carvajal AR, Pajuelo JG, Padilla MCA, Armashernandez MJ "Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal. Alfuzosin: The pharmacokinetic and pharmacodynamic interactions between alfuzosin and other alpha-blockers used for high blood pressure or for benign prostatic hyperplasia have not been determined. However, interactions or side effects dizziness, hypotension, syncope, etc. Of the 506 patients in the DIAMOND studies who had atrial fibrillation or flutter at baseline, 12% of patients in the Tikosyn group and 2% of patients in the placebo group had converted to normal sinus rhythm after one month. In those patients converted to normal sinus rhythm, 79% of the Tikosyn group and 42% of the placebo group remained in normal sinus rhythm for one year. Tikosyn. Of these, 4 cases occurred within the first 3 days of dosing and 3 cases occurred between Day 4 and the conclusion of the study. Ocular side effects including Intraoperative Floppy Iris Syndrome IFIS have been observed in some patients undergoing phacoemulsification cataract surgery while being treated with alpha-1 blockers. Concomitant use of ketoconazole is contraindicated. Ketoconazole at 400 mg daily the maximum approved prescription dose co-administered with Tikosyn 500 mcg BID for 7 days has been shown to increase dofetilide C max by 53% in males and 97% in females, and AUC by 41% in males and 69% in females. Other conditions, such as a or can cause symptoms similar to those of prostatitis. escitalopram patch price us
price terazosin vomiting, buy terazosin spain, buying terazosin online reviews, shop terazosin instrukcija, buy now terazosin online store, terazosin april, terazosin generic levothyroxine, order cheap terazosin visa uk, purchase terazosin pharmacy australia, buy real terazosin, can u terazosin, when will generic terazosin be on the market, buy terazosin china, buy terazosin pill, cheap terazosin buy store usa, virginia terazosin, purchase now terazosin mastercard, purchase terazosin uses, cost terazosin manufacturer, terazosin walmart brand, pharmacy terazosin kada, terazosin order payment usa, generic terazosin trip, terazosin purchase online mastercard uk, cheap terazosin purchase shop, terazosin 750, pharmacy terazosin vs, cheap terazosin bangkok, terazosin generic brand names, terazosin cumpara online, can you buy terazosin over counter, buy terazosin indication, generic terazosin order online uk, generic terazosin availability, average wholesale price for terazosin, order cheap terazosin pharmacy, purchase now cheap terazosin canada, order terazosin online visa canada, buy terazosin without presc, terazosin purposes, purchase terazosin shop australia, where to purchase terazosin shopping, terazosin price kroger, terazosin buy now shopping usa, store terazosin together, terazosin cream purchase, mail order terazosin pharmacy usa, terazosin online uk next day delivery, river pharmacy terazosin, generic terazosin buy uk, cheapest terazosin mail order online, non prescription terazosin, cheap terazosin order shop, cheap terazosin uk only, pharmacy buy terazosin usa, price terazosin, terazosin patch price us, buy terazosin next day delivery
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. In the DIAMOND studies, all patients were hospitalized for at least 3 days after treatment was initiated and monitored by telemetry. Not known whether terazosin is distributed into breast milk. What should I discuss with my healthcare provider before taking terazosin Hytrin? Cushman WC, Ford CE, Cutler JA, et al. Success and predictors of blood pressure control in diverse North American settings: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ALLHAT. J Clin Hypertens Greenwich. ibne.info fludrocortisone
Prilocaine; Epinephrine: Sympathomimetics, such as epinephrine, can antagonize the effects of alpha-blockers when administered concomitantly. Patients receiving alpha-blockers can exhibit a decreased pressor response to epinephrine, resulting in an increased risk of developing hypotension and tachycardia. Blood pressure should be monitored closely. Weber MA, Laragh JH. Hypertension: steps forward and steps backward. The Joint National Committee fifth report. Arch Intern Med. To decrease risk of excessive hypotension and syncope, initiate therapy at low dose and titrate carefully, lessen level of salt restriction, and avoid diuretics just prior to initiation of terazosin therapy.
If you use 1 dose daily and miss a dose, use it as soon as you remember. If you do not remember until the next day, skip the missed dose and resume your usual dosing schedule. Terazosin capsules relax the tightness of a certain type of muscle in the prostate and at the opening of the bladder. Number of patients evaluated for QTc change: 478 Tikosyn, 167 placebo.
Geriatric patients may be more sensitive to the hypotensive and adverse effects dry mouth and drowsiness of terazosin. Monitor older adult patients closely. According to the Beers Criteria, terazosin is considered a potentially inappropriate medication PIM for use in geriatric patients and should be avoided as routine treatment of hypertension in this population due to the high risk of orthostatic hypotension and the availability of alternative agents with a superior benefit to risk profile. In addition, the Beers expert panel recommends avoiding terazosin in geriatric patients with syncope due to an increased risk of orthostatic hypotension or bradycardia, and also avoiding terazosin in elderly females with urinary incontinence, regardless of cause or type, because aggravation of incontinence may occur. The federal Omnibus Budget Reconciliation Act OBRA regulates medication use in residents of long-term care facilities LTCFs. According to the OBRA guidelines, antihypertensive regimens should be individualized to achieve the desired outcome while minimizing adverse effects. Antihypertensives may cause dizziness, postural hypotension, fatigue, and there is an increased risk for falls. Terazosin can cause significant hypotension and syncope during the first few doses; therefore, the dose should be administered at bedtime initially, and the drug slowly titrated as needed. There are many drug interactions that can potentiate the effects of antihypertensives. Some agents require a gradual taper to avoid adverse consequences caused by abrupt discontinuation.